Anti-CD105 (Endoglin) (Human) mAb
| Code | Size | Price |
|---|
| MBL-W357-3 | 100 ul | £323.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b κ
Antibody Clonality: Monoclonal
Antibody Clone: 3G4A6
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
FCM - 1-10 ug/mL
Background:
Endoglin, also known as CD105, is a type I membrane protein. Endoglin is a major glycoprotein located on the cell surface of vascular endothelium. It is involved in regulation of angiogenesis. In cancer tissue, endoglin is over-expressed in proliferating endothelial cells which line tumor blood vessels. Moreover, tumor cells also express endoglin in prostate cancer and melanoma. Endoglin might be a good candidate to be used for tumor imaging and for targeted cancer therapy.
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 2022
Immunogen Translated:
Human CD105 (Endoglin) expressed Ba/F3 transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity:
This antibody reacts with human CD105
(Endoglin) on Flow cytometry.
Target:
CD105 (Endoglin)
References
1) Castonguay, R., et al., J. Biol. Chem. 286, 30034-30046 (2011)
2) Chen, Y., et al., Ann. Neurol. 66, 19-27 (2009)
3) Lee, N. Y., et al., J. Biol. Chem. 283, 32527-32533 (2008)
4) Kojima, T and Kitamura, T. Nat. Biotechnol. 17, 487-490 (1999)
5) Bell?n, T., et al., Eur. J. Immunol. 23, 2340-2345 (1993)