Anti-CD40 (Human) mAb Functional Grade
| Code | Size | Price |
|---|
| MBL-FP10052505 | 50 ug | £291.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: 5C3
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Functional Study
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.
Concentration:
1 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
Target:
CD40
References
Yagita, H., et al., Proc Natl Acad Sci U S A. 86, 645-649 (1989) Nakamura, T., et al., J Immunol. 145, 3628-3634 (1990) Kato, K., et al., J Exp Med. 176, 1241-1249 (1992)