Anti-Integrin alpha v beta 3 (CD51/CD61) (Human) mAb Functional Grade
| Code | Size | Price |
|---|
| MBL-FP10172505 | 50 ug | £277.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: 23C6
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Functional Study
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor. The complex binds to other ligands such as CD29, fibrinogen, fibrinectin, vWf, laminin, and thrombospondin. It is expressed by endothelial cells, osteoclasts, melanoma cells, and at low levels on platelets and macrophages. The 23C6 antibody is reported to be able to block the receptors ability to form interactions with some of its ligands.
Concentration:
1 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
Target:
Integrin alpha v beta 3
References
Nicolls, M. R., et al., Transplantation. 55, 459-468 (1993) Morris, D. L., & Komocsar, W. J., J Pharmacol Toxicol Methods. 37, 37-46 (1997) Tran, G. T., et al., Int Immunol. 13, 1109-1120 (2001)