MBL

Anti-CD28 (Human) mAb

Product Code:
 
MBL-FP10612010
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
CD28.2
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Flow Cytometry
  • Functional Study
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
Shipping:
 
4°C
Storage:
 
4°C
 

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MBL-FP10612010100 ug£229.00
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  • Further Information
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Further Information

Background:
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
Concentration:
0.5 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
CD28

Documents

References

Alterman, L. A., et al., Eur J Immunol. 20, 1597-1602 (1990) Crowley, M., et al., Cell Immunol. 118, 108-125 (1989) Wenger, R. H., et al., J. Biol. Chem. 268, 23345-23352 (1993)