Anti-CD28 (Human) mAb-PE-Cy7
| Code | Size | Price |
|---|
| MBL-FP10617702 | 25 tests | £284.00 |
Quantity:
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Overview
Host Type: Mouse
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: CD28.2
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
Concentration:
5 uL (0.25 ug)/test
Conjugate:
PE
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
CD28
References
Trowbridge, I. S., et al., Immunogenetics. 15, 299-312 (1982) Lesley, J., & Trowbridge, I. S., Immunogenetics. 15, 313-320 (1982) Nedvetzki, S., et al., J Autoimmun. 13, 39-47 (1999)