Anti-c-Myc (Human)
| Code | Size | Price |
|---|
| MBL-FP10922002 | 25 ug | £229.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: 9E10
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The 9E10 monoclonal antibody specifically reacts with the human c-Myc p67 molecule, a proto-oncogene from the Myc family, which is important in transformation, proliferation, and differentiation. This gene is expressed during embryonic development, in some adult tissues, and is amplified in some tumors. Inside the cell, the gene is localized in the nucleus or cytoplasm. C-Myc is characterized by a Leucine zipper, a basic region, and a helix-loop-helix, which allow the formation of a heterodimer Myc-Max that binds to DNA, and activates the transcription. The 9E10 antibody recognizes the human c-Myc and can be used for Myc-tagged protein detection. It was obtained by using synthetic peptide similar to the terminal domain of human c-Myc as an immunogen.
Concentration:
0.5 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
c-Myc
References
Schlossman, S. F., Leukocyte typing V. Oxford University Press (1995) Zhang, B., et al., Ann Rheum Dis. 67, 1037-1040 (2008) Chapel, A., et al., J Virol. 66, 3966-3970 (1992)