Anti-TNF-Alpha (Human) mAb
| Code | Size | Price |
|---|
| MBL-FP11052005 | 50 ug | £270.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: MAb11
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Flow Cytometry
- Immunocytofluorescence (ICF)
- Immunohistochemistry (IHC)
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.
Concentration:
0.5 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
TNF-Alpha
References
Ledbetter, J. A., et al., Immunol Rev. 47, 63-90 (1979) Thomas, M. L., Annu Rev Immunol. 7, 339-369 (1989) Simon, D. I., et al., J Clin Invest. 105, 293-300 (2000)