Anti-CD70 (Mouse) mAb Functional Grade
| Code | Size | Price |
|---|
| MBL-FP20042550 | 500 ug | £603.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b κ
Antibody Clonality: Monoclonal
Antibody Clone: FR70
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Functional Study
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
Concentration:
1 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
Target:
CD70
References
Akashi, S., et al., J Exp Med. 198, 1035-1042 (2003) Qi, H. Y., & Shelhamer, J. H., J. Biol. Chem. 280, 38969-38975 (2005) Shimazu, R., et al., J Exp Med. 189, 1777-1782 (1999)