Anti-CD45 (Mouse) mAb-FITC
Code | Size | Price |
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MBL-FP20275010 | 100 ug | £215.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b κ
Antibody Clonality: Monoclonal
Antibody Clone: 30-F11
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The 30-F11 monoclonal antibody specifically reacts with all isoforms of CD45 and also with the alloantigens CD45.1 and CD45.2 (LCA). CD45 is a transmembrane glycoprotein, expressed by all the hematopoietic cells, except for platelets and mature erythrocytes, which distinguishes the leukocytes from the non-hematopoietic cells. The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region?s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons.The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction.
Concentration:
0.5 mg/mL
Conjugate:
FITC
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
CD45
References
Fleming, T. J., et al., J Immunol. 151, 2399-2408 (1993) Daley, J. M., et al., J Leukoc Biol. 83, 64-70 (2008) Dietlin, T. A., et al., J Leukoc Biol. 81, 1205-1212 (2007)