Anti-CTLA-4 (CD152) (Mouse) mAb Functional Grade
| Code | Size | Price |
|---|
| MBL-FP20462510 | 100 ug | £326.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: UC10-4F10-11
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
Concentration:
2 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
Target:
CTLA-4
References
Sanchez-Madrid, F., et al., J Exp Med. 158, 586-602 (1983) Ault, K. A., & Springer, T. A., J Immunol. 126, 359-364 (1981) Springer, T., et al., Eur J Immunol. 8, 539-551 (1978)