Anti-PD-L1/B7-H1 (CD274) (Mouse) mAb Functional Grade
| Code | Size | Price |
|---|
| MBL-FP20562510 | 100 ug | £291.00 |
Quantity:
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Overview
Host Type: Rat
Antibody Isotype: IgG2b κ
Antibody Clonality: Monoclonal
Antibody Clone: 10F.9G2
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Functional Study
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses.
Concentration:
2 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
Target:
PD-L1/B7-H1
References
Andrew, D. P., et al., J Immunol. 153, 3847-3861 (1994) Berlin, C., et al., Cell. 74, 185-195 (1993) Rivera-Nieves, J., et al., J Immunol. 174, 2343-2352 (2005)