Anti-AITR/GITR (CD357) (Mouse) mAb-APC
| Code | Size | Price |
|---|
| MBL-FP20618010 | 100 ug | £492.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: DTA-1
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The DTA-1 monoclonal antibody specifically reacts with mouse Glucocorticoid-Induced TNFR-related protein, also known as GITR and TNFRSF18, a 66-70 kDa homodimer glycoprotein, detected in the T cells treated with glucocorticoid dexamethasone. GITR is also expressed in na?ve mice by CD25+/CD4+/CD8a- thymocytes and on CD25+/CD4+/CD45RB-low splenocytes. Low levels were detected in splenic CD25+/CD4+/CD45RB-low T cells, B cells, dendritic cells and macrophages. A GITR ligand was detected on dendritic cells, macrophages and B cells.The DTA-1 antibody stimulates GITR and abrogates suppression by T regulatory cells (Treg), without affecting their proliferation. DTA-1 administration or the removal of GITR-expressing cells led to organ specific autoimmune disease.
Concentration:
0.2 mg/mL
Conjugate:
APC
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
AITR/GITR
References
Huppert, S. S., et al., Nature. 405, 966-970 (2000) Milner, L. A., & Bigas, A., Blood. 93, 2431-2448 (1999) Varnum-Finney, B., et al., Blood. 91, 4084-4091 (1998)