Anti-Foxp3 (Mouse) mAb-APC
| Code | Size | Price |
|---|
| MBL-FP20838002 | 25 ug | £416.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: MF23
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The MF23 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression. Mutations of Foxp3 result in the ?scurfy? mice phenotype. It is reported that the MF23 antibody recognizes an epitope between 1-87 amino acids in the N-terminal domain of mouse Foxp3.
Concentration:
0.2 mg/mL
Conjugate:
APC
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
Foxp3
References
Norton, A. J., & Isaacson, P. G., Am J Pathol. 128, 225-240 (1987) Hua, Z. X., et al., Hum Pathol. 29, 1441-1446 (1998) Ioachim, H. L., et at., Am J Surg Pathol. 20, 64-71 (1996)