Anti-TCR beta (Mouse) mAb-V450
Code | Size | Price |
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MBL-FP20884010 | 100 ug | £367.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: H57-597
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Background:
The H57-597 monoclonal antibody is specific for the beta chain of the mouse T cell Receptor (TCR). The crosslinking induces activation and proliferation of T cells, as a plate-bound or a soluble H57-597, or the plate-bound antibody can induce apoptosis, based on assay conditions. The beta chain of the TCR can combine with the alpha chain of the receptor to produce the alpha-beta TCR, which is expressed by the NKT cells, by the NK1.1+ thymocytes and most of the T cells. The beta chain does not react with the gamma-delta TCR-bearing cells, expressed by a small number of T cells. This antibody can be used as a phenotypic marker for the TCR beta expressing cells or for the functional purpose of TCR-mediated cell activation or apoptosis.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Concentration:
0.2 mg/mL
Conjugate:
V450
Formulation:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Target:
TCR beta
References
Oxvig, C., et al. , Proc Natl Acad Sci U S A. 96, 2215-2220 (1999) Diamond, M. S. & Springer, T. A. , J Cell Biol. 120, 545-556 (1993) Shimaoka, M., et al. , Nat Struct Biol. 7, 674-678 (2000)