anti-LAIR1 (human), Rabbit Monoclonal (RM498)
Code | Size | Price |
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REV-31-1390-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM498
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Blue Ice
Storage:
Short-term: 4°C. Long-term: -20°C.
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Further Information
Alternate Names/Synonyms:
Leukocyte-associated Immunoglobulin-like Receptor 1; CD305
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freez/thaw cycles.
Immunogen:
Recombinant extracellular domain of human LAIR1.
Long Description:
Recombinant Antibody. This antibody reacts to human LAIR1. Isotype: Rabbit IgG. Immunogen: Recombinant extracellular domain of human LAIR1. Application: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on the cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in the recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. LAIR1 plays a role in immune response homeostasis, and extracellular matrix remodeling and it is overexpressed in many high-grade cancers.
NCBI Uniprot Number:
Q6GTX8
Package Type:
Vial
Product Description:
LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on the cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in the recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. LAIR1 plays a role in immune response homeostasis, and extracellular matrix remodeling and it is overexpressed in many high-grade cancers.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human LAIR1.
Transportation:
Non-hazardous
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.