anti-Galectin-9 (human), Rabbit Monoclonal (RM499)
Code | Size | Price |
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REV-31-1391-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM499
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Blue Ice
Storage:
Short-term: 4°C. Long-term: -20°C.
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Further Information
Alternate Names/Synonyms:
Gal-9; Ecalectin; Tumor Antigen HOM-HD-21; TIM-3 Ligand; T Cell Immunoglobulin and Mucin Domain-containing Protein 3 Ligand
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freez/thaw cycles.
Immunogen:
A peptide corresponding to the N-terminus of human Galectin-9 (Gal-9).
Long Description:
Recombinant Antibody. This antibody reacts to human Galectin-9. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the N-terminus of human Galectin-9 (Gal-9). Application: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Galectin-9 (Gal-9), a beta-galactoside-binding protein, primarily plays an immunosuppressive role in the tumor microenvironment, via binding with several cell surface receptors expressed on immune cells. Although Gal-9 was initially identified as a ligand for T-cell immunoglobulin and mucin domain?containing molecule 3 (TIM-3) in the induction of T-cell death, it also binds to other immunoregulatory receptors. For instance, Gal-9 binding to the innate receptor dectin-1 promotes M2 polarization of macrophages that suppresses antitumor immune responses. Gal-9 has also been shown to promote the differentiation of regulatory T cells (Tregs) through interaction with cluster of differentiation 44 (CD44) and drive the expansion of Tregs through binding with death receptor 3. The aberrantly high expression of Gal-9 in a range of cancers suggests that Gal-9 could be significant both as a biomarker and a therapeutic target.
NCBI Uniprot Number:
O00182
Package Type:
Vial
Product Description:
Galectin-9 (Gal-9), a beta-galactoside-binding protein, primarily plays an immunosuppressive role in the tumor microenvironment, via binding with several cell surface receptors expressed on immune cells. Although Gal-9 was initially identified as a ligand for T-cell immunoglobulin and mucin domain?containing molecule 3 (TIM-3) in the induction of T-cell death, it also binds to other immunoregulatory receptors. For instance, Gal-9 binding to the innate receptor dectin-1 promotes M2 polarization of macrophages that suppresses antitumor immune responses. Gal-9 has also been shown to promote the differentiation of regulatory T cells (Tregs) through interaction with cluster of differentiation 44 (CD44) and drive the expansion of Tregs through binding with death receptor 3. The aberrantly high expression of Gal-9 in a range of cancers suggests that Gal-9 could be significant both as a biomarker and a therapeutic target.
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human Galectin-9.
Transportation:
Non-hazardous
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.