anti-UP2 (Uroplakin-2) (human), Rabbit Monoclonal (RM507)
| Code | Size | Price |
|---|
| REV-31-1399-00-R100 | 100 ul | £455.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Recombinant Antibody
Antibody Clone: RM507
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Blue Ice
Storage:
Short-term: 4°C. Long-term: -20°C.
Documents
Further Information
Alternate Names/Synonyms:
Uroplakin-2; UPII; Uroplakin II
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Handling Advice:
Avoid freez/thaw cycles.
Immunogen:
A peptide corresponding to residues near the C-terminus of human UP2.
Long Description:
Recombinant Antibody. This antibody reacts to human UP2. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to residues near the C-terminus of human UP2. Application: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. The protein components of uroplaques are composed of uroplakins (UPs), which are a family of transmembrane proteins, including UPIa (27 kDa), UPIb (28 kDa), UPII (15 kDa), and UPIIIa (47 kDa). UPs are exclusively expressed in the normal urothelium and are undetectable in non-urothelial tissues. They are usually present at the apical surface and cytoplasm of umbrella cells but absent in the intermediate and basal cells. Although UPs are the major differentiation products of the urothelium, they are not significantly downregulated during urothelial malignant transformation. Using immunohistochemical staining it was shown that more than half of invasive and metastatic urothelial carcinomas (UCs) continued to express UPs. Uroplakin II (UP II) is a 15 kDa protein component of urothelial plaques that enhance the permeability barrier of the urothelium. Uroplakin II (UPII) is considered as a sensitive marker for urothelial carcinoma (UC).
NCBI Uniprot Number:
O00526
Package Type:
Vial
Product Description:
The protein components of uroplaques are composed of uroplakins (UPs), which are a family of transmembrane proteins, including UPIa (27 kDa), UPIb (28 kDa), UPII (15 kDa), and UPIIIa (47 kDa). UPs are exclusively expressed in the normal urothelium and are undetectable in non-urothelial tissues. They are usually present at the apical surface and cytoplasm of umbrella cells but absent in the intermediate and basal cells. Although UPs are the major differentiation products of the urothelium, they are not significantly downregulated during urothelial malignant transformation. Using immunohistochemical staining it was shown that more than half of invasive and metastatic urothelial carcinomas (UCs) continued to express UPs. Uroplakin II (UP II) is a 15 kDa protein component of urothelial plaques that enhance the permeability barrier of the urothelium. Uroplakin II (UPII) is considered as a sensitive marker for urothelial carcinoma (UC).
Purity:
Protein A purified.
Source / Host:
Rabbit
Specificity:
This antibody reacts to human UP2.
Transportation:
Non-hazardous
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.