Recombinant cAMP Protein Kinase Catalytic Subunit Monoclonal Antibody
| Code | Size | Price |
|---|
| E-AB-81539-50uL | 50uL | £184.00 |
Quantity:
| E-AB-81539-100uL | 100uL | £251.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: R07-8H3
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
Recombinant cAMP Protein Kinase Catalytic Subunit
Background:
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.
Buffer:
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Calculated MW:
41kDa
Concentration:
300 ug/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:2000 IHC 1:50-1:100 IF 1:50-1:100
Immunogen:
A synthetic peptide of human cAMP Protein Kinase Catalytic subunit
ObservedMW:
41kDa
Purification method:
Affinity Purified
Target Synonym:
cAMP dependent protein kinase alpha catalytic subunit;cAMP dependent protein kinase beta catalytic subunit;cAMP dependent protein kinase catalytic beta subunit isoform 4ab;cAMP dependent protein kinase catalytic subunit alpha;cAMP dependent protein kinase catalytic subunit alpha;isoform 1;cAMP dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha;KAPCA;PKA C alpha;PKA C beta;PKA C-alpha;PKACA;PKACB;PPNAD4;PRKACA;PRKACAA;PRKACB;Protein kinase A catalytic subunit alpha;Protein kinase A catalytic subunit;Protein kinase A catalytic subunit beta;Protein kinase cAMP dependent catalytic alpha;Protein kinase cAMP dependent catalytic beta
UNIProt ID:
P17612