Recombinant Alkaline Phosphatase Monoclonal Antibody
| Code | Size | Price |
|---|
| E-AB-81527-50uL | 50uL | £184.00 |
Quantity:
| E-AB-81527-100uL | 100uL | £251.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: R08-6H0
Regulatory Status: RUO
Target Species:
- Human
- Rat
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
Alkaline Phosphatase
Background:
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
Buffer:
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Calculated MW:
57kDa
Concentration:
300 ug/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-1:2000 IHC 1:50-1:100 IF 1:50-1:100
Immunogen:
A synthetic peptide of human Alkaline Phosphatase, Tissue Non-Specific
ObservedMW:
80kDa
Purification method:
Affinity Purified
Target Synonym:
AKP2;Alkaline phosphatase liver/bone/kidney;Alkaline phosphatase liver/bone/kidney isozyme;Alkaline phosphatase tissue nonspecific isozyme;Alkaline phosphatase;tissue-nonspecific isozyme;Alkaline phosphomonoesterase;Alpl;AP TNAP;AP-TNAP;APTNAP;BAP;FLJ40094;FLJ93059;Glycerophosphatase;HOPS;Liver/bone/kidney type alkaline phosphatase;MGC161443;MGC167935;PHOA;PPBT;Tissue non specific alkaline phosphatase;Tissue nonspecific ALP;TNAP;TNSALP
UNIProt ID:
P05186
References
- https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.23245