Recombinant SQSTM1/p62 Monoclonal Antibody
| Code | Size | Price |
|---|
| E-AB-81512-50uL | 50uL | £184.00 |
Quantity:
| E-AB-81512-100uL | 100uL | £251.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: R08-4H8
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
SQSTM1/p62
Background:
Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
Buffer:
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Calculated MW:
48kDa
Concentration:
300 ug/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:1000
Immunogen:
Recombinant protein of human SQSTM1/p62
ObservedMW:
62kDa
Purification method:
Affinity Purified
Target Synonym:
A170;DMRV;EBI 3 associated protein of 60 kDa;EBI 3 associated protein p60;EBI3 associated protein of 60 kDa;EBI3 associated protein p60;EBI3-associated protein of 60 kDa;EBIAP;FTDALS3;MGC127197;ORCA;OSF-6;Osi;OSIL;Oxidative stress induced like;p60;p62;p62B;Paget disease of bone 3;PDB 3;PDB3;Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa;Phosphotyrosine independent ligand for the Lck SH2 domain p62;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;PKC-zeta-interacting protein;Protein kinase C-zeta-interacting protein;Sequestosome 1;Sequestosome-1;SQSTM 1;SQSTM;Sqstm1;STAP;STONE14;Ubiquitin binding protein p62;Ubiquitin-binding protein p62;ZIP 3;ZIP;ZIP3
UNIProt ID:
Q13501