SMG7 Polyclonal Antibody

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Elabscience
Product Code: E-AB-32926
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-32926-20uL20uL£125.00
Quantity:
E-AB-32926-60uL60uL£172.00
Quantity:
E-AB-32926-120uL120uL£237.00
Quantity:
E-AB-32926-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Western Blot analysis of Jurkat cells using SMG7 Polyclonal Antibody at dilution of 1:2000.
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Western Blot analysis of Hela cells using SMG7 Polyclonal Antibody at dilution of 1:2000.
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Western Blot analysis of Jurkat cells using SMG7 Polyclonal Antibody at dilution of 1:2000.
Western Blot analysis of Hela cells using SMG7 Polyclonal Antibody at dilution of 1:2000.

Documents

Further Information

Abbreviation:
SMG7
Background:
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.SMG7 (SMG7, Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. GO annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is SMG6.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Calculated MW:
127kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Immunogen:
Synthesized peptide derived from the Internal region of human SMG7
ObservedMW:
127kDa
Purification method:
Affinity purification
Target Synonym:
breast cancer-associated antigen SGA-56M;C1orf16;EST1 like protein C;EST1 telomerase component homolog C;EST1-like protein C;EST1C;ever shorter telomeres 1C;FLJ23717;hSMG-7;nonsense mediated mRNA decay factor (C. elegans);Protein SMG7;SGA56M;SMG 7;SMG-7 homolog;Smg7;SMG7
UNIProt ID:
Q92540

References

  • https://academic.oup.com/nar/article-abstract/48/15/8626/5867419