Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5
| Code | Size | Price |
|---|
| PKSH033872-10ug | 10ug | £242.00 |
Quantity:
| PKSH033872-50ug | 50ug | £574.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Cell Culture
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Abbreviation:
IL-36RN;IL-1F5
Accession:
Q9UBH0
Activity:
Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is 12.0 ng/ml.
Background:
Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family). IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9). Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.
Calculated MW:
16.8 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
None
ObservedMW:
17 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Val2-Asp155
Target Synonym:
Interleukin-36 Receptor Antagonist Protein;FIL1 Delta;IL-1-Related Protein 3;IL-1RP3;Interleukin-1 HY1;IL-1HY1;Interleukin-1 Delta;IL-1 Delta;Interleukin-1 Family Member 5;IL-1F5;Interleukin-1 Receptor Antagonist Homolog 1;IL-1ra Homolog 1;Interleukin-1-Like Protein 1;IL-1L1;IL36RN;FIL1D;IL1F5;IL1HY1;IL1L1;IL1RP3
UNIProt ID:
Q9UBH0