Recombinant MERS-CoV S-trimer Protein?(R751S, C-6His)(Active)
| Code | Size | Price |
|---|
| PKSV030287-50ug | 50ug | £382.00 |
Quantity:
| PKSV030287-500ug | 500ug | £2,277.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Virus
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt store it immediately at < -20°C.
Storage:
Store at < -20°C stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Further Information
Abbreviation:
Spike
Accession:
AFS88936.1
Activity:
Immobilized MERS-CoV S-trimer Protein (R751S)-His(PKSV030287) at 5ug/ml (100 ul/well) can bind Human CD26-Fc(PKSH033696), The ED50 of Human CD26-Fc(PKSH033696) is 27.16 ng/ml.
Background:
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Calculated MW:
145 kDa
Expression Host:
HEK293 Cells
Formulation:
Supplied as a 0.2 um filtered solution of PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
170-220 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Tyr18-Lys1294(R751S)
Target Synonym:
MERS-CoV S protein;MERS-CoV S-trimer Protein;MERS-CoV Spike glycoprotein;MERS-CoV S glycoprotein