Recombinant Human Signal Transducer CD24/CD24 (C-Fc)

Elabscience
Product Code: PKSH033968
Product Group: Recombinant Proteins
Supplier: Elabscience
CodeSizePrice
PKSH033968-10ug10ug£183.00
Quantity:
PKSH033968-50ug50ug£392.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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Immobilized Anti-Human CD24 mAb at 2ug/ml (100 ul/well) can bind Human CD24-Fc: Biotinylated by NHS-biotin prior to testing. The ED50 of Human CD24-Fc is 7.62 ng/ml.

Immobilized Anti-Human CD24 mAb at 2ug/ml (100 ul/well) can bind Human CD24-Fc: Biotinylated by NHS-biotin prior to testing. The ED50 of Human CD24-Fc is 7.62 ng/ml.

Documents

Further Information

Abbreviation:
CD24
Accession:
P25063
Activity:
Immobilized Anti-Human CD24 mAb at 2ug/ml (100 ul/well) can bind Human CD24-Fc: Biotinylated by NHS-biotin prior to testing. The ED50 of Human CD24-Fc is 7.62 ng/ml.
Background:
Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.
Calculated MW:
29.8 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc
ObservedMW:
33-50 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ser27-Gly 59
Target Synonym:
Signal transducer CD24;Small cell lung carcinoma cluster 4 antigen;CD24;CD24A
UNIProt ID:
P25063