Recombinant Human TSLP R/CRLF2 (C-Fc)
| Code | Size | Price |
|---|
| PKSH033923-10ug | 10ug | £183.00 |
Quantity:
| PKSH033923-50ug | 50ug | £392.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Bio-Layer Interferometry
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Abbreviation:
TSLP R;CRLF2
Accession:
Q9HC73
Activity:
Loaded Human TSLP-His on HIS1K Biosensor, can bind Human TSLP R-Fc with an affinity constant of 37.97nM as determined in BLI assay.
Background:
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction . The TSLP R and IL-7 R alpha are coexpressed primarily on monocytes and dendritic cells and at lower levels in lymphoid cells. TSLP has been shown to induce the release of T cell-attracting chemokines from monocytes and enhance the maturation of CD11c+ dendritic cells.
Calculated MW:
50.9 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-Fc
ObservedMW:
60-80 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Gly25-Lys231
Target Synonym:
CRL2;CRL2cytokine receptor CRL2 precusor;CRLF2;CRLF2Y;CRLM-2;Cytokine receptor-like 2;cytokine receptor-like factor 2;ILXR;IL-XR;P2RY8/CRLF2 fusion;PCOR1;TSLP R;TSLP receptor;TSLPR
UNIProt ID:
Q9HC73