Recombinant Human PVRIG (C-mFc)
| Code | Size | Price |
|---|
| PKSH034019-10ug | 10ug | £183.00 |
Quantity:
| PKSH034019-50ug | 50ug | £392.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Further Information
Abbreviation:
PVRIG
Accession:
Q6DKI7
Activity:
Immobilized Human PVRIG-mFc(Cat#PKSH034019) at 10ug/ml (100 ul/well) can bind Biotinylated Human Nectin-2-His-Avi(Cat#PKSH034032). The ED50 of Biotinylated Human Nectin-2-His-Avi(Cat#PKSH034032) is 0.42 ug/ml.
Background:
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
Calculated MW:
40.1 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-mFc
ObservedMW:
45-55 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Thr41-Asp171
Target Synonym:
C7orf15;CD112R;PVRIG;transmembrane protein PVRIG;C7orf15MGC138295;MGC104322;MGC138297;MGC2463
UNIProt ID:
Q6DKI7