HSD11B2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-67942-60uL | 60uL | £210.00 |
Quantity:
| E-AB-67942-120uL | 120uL | £291.00 |
Quantity:
| E-AB-67942-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HSD11B2
Background:
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Buffer:
PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Calculated MW:
44kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:1000
Immunogen:
Recombinant fusion protein of human HSD11B2
ObservedMW:
44kDa
Purification method:
Affinity purification
Target Synonym:
HSD11B2;AME;AME1;HSD11K;HSD2;SDR9C3
UNIProt ID:
P80365