BRCA2 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-67462-60uL | 60uL | £210.00 |
Quantity:
| E-AB-67462-120uL | 120uL | £291.00 |
Quantity:
| E-AB-67462-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Application: Immunofluorescence (IF)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
BRCA2
Background:
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IF 1:50-1:200
Immunogen:
Recombinant fusion protein of human BRCA2 (NP_000050.2).
Purification method:
Affinity purification
Target Synonym:
BRCA2;BRCC2;BROVCA2;FACD;FAD;FAD1;FANCD;FANCD1;GLM3;PNCA2;XRCC11
UNIProt ID:
P51587