NOTCH3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-66095-60uL | 60uL | £210.00 |
Quantity:
| E-AB-66095-120uL | 120uL | £291.00 |
Quantity:
| E-AB-66095-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
NOTCH3
Background:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
A synthetic peptide of human NOTCH3 (NP_000426.2).
Purification method:
Affinity purification
Target Synonym:
NOTCH3;CADASIL;CADASIL1;CASIL;IMF2;LMNS;notch 3
UNIProt ID:
Q9UM47