HMGCR Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-66762-60uL | 60uL | £210.00 |
Quantity:
| E-AB-66762-120uL | 120uL | £291.00 |
Quantity:
| E-AB-66762-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HMGCR
Background:
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:100
Immunogen:
Recombinant fusion protein of human HMGCR (NP_000850.1).
Purification method:
Affinity purification
Target Synonym:
HMGCR;LDLCQ3;HMGCR
UNIProt ID:
P04035
References
- https://www.sciencedirect.com/science/article/pii/S0306452218305414