p27 KIP 1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-66512-60uL | 60uL | £210.00 |
Quantity:
| E-AB-66512-120uL | 120uL | £291.00 |
Quantity:
| E-AB-66512-200uL | 200uL | £431.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
p27 KIP 1
Background:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
22kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000 IHC 1:50-1:100
Immunogen:
A synthetic peptide of human p27 KIP 1 (NP_004055.1).
ObservedMW:
30kDa
Purification method:
Affinity purification
Target Synonym:
CDKN1B;CDKN4;KIP1;MEN1B;MEN4;P27KIP1;p27 KIP 1
UNIProt ID:
P46527