(KO Validated) CTCF Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-67371-60uL | 60uL | £224.00 |
Quantity:
| E-AB-67371-120uL | 120uL | £317.00 |
Quantity:
| E-AB-67371-200uL | 200uL | £465.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
CTCF
Background:
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
83kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant protein of human CTCF.
ObservedMW:
140kDa
Purification method:
Affinity purification
Target Synonym:
Transcriptional repressor CTCFL;Brother of the regulator of imprinted sites;CCCTC-binding factor;CTCF paralog;CTCF-like protein;Cancer/testis antigen 27;CT27;Zinc finger protein CTCF-T;CTCFL;BORIS
UNIProt ID:
P49711