Phospho-SMAD3 (Ser425) Monoclonal Antibody
| Code | Size | Price |
|---|
| E-AB-51043-20uL | 20uL | £125.00 |
Quantity:
| E-AB-51043-60uL | 60uL | £172.00 |
Quantity:
| E-AB-51043-120uL | 120uL | £237.00 |
Quantity:
| E-AB-51043-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: Clone:4C5
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Application: Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
Phospho-SMAD3 (Ser425)
Background:
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-300
Immunogen:
Synthetic Peptide of Phospho-Smad3 (Ser425)
Purification method:
Protein A purification
Target Synonym:
DKFZP586N0721;DKFZp686J10186;hMAD 3;hMAD-3;hSMAD3;HSPC193;HST17436;JV15 2;JV15-2;JV152;LDS1C;LDS3;MAD (mothers against decapentaplegic Drosophila) homolog 3;MAD homolog 3;Mad homolog JV15 2;Mad protein homolog;MAD;mothers against decapentaplegic homolog 3;Mad3;MADH 3;MADH3;MGC60396;Mothers against decapentaplegic homolog 3;Mothers against DPP homolog 3;SMA and MAD related protein 3;SMAD 3;SMAD;SMAD family member 3;SMAD;mothers against DPP homolog 3;Smad3;SMAD3
UNIProt ID:
P84022
References
- https://www.karger.com/Article/Abstract/452571