WRN Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-53558-20uL | 20uL | £125.00 |
Quantity:
| E-AB-53558-60uL | 60uL | £172.00 |
Quantity:
| E-AB-53558-120uL | 120uL | £237.00 |
Quantity:
| E-AB-53558-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
WRN
Background:
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.8 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human WRN
Purification method:
Antigen affinity purification
Target Synonym:
DKFZp686C2056;DNA helicase;DNA helicase; RecQ like type 3;Exonuclease WRN;HGNC 12791;OTTHUMP00000225301;RecQ protein-like 2;RecQ-like type 3;RecQ3;RECQL2;RECQL3;Werner syndrome ATP-dependent helicase;Werner syndrome helicase;Werner syndrome protein;Werner syndrome; RecQ helicase like;WRN;WRN
UNIProt ID:
Q14191