XAB2 Polyclonal Antibody

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Elabscience
Product Code: E-AB-53550
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-53550-20uL20uL£125.00
Quantity:
E-AB-53550-60uL60uL£172.00
Quantity:
E-AB-53550-120uL120uL£237.00
Quantity:
E-AB-53550-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using XAB2 Polyclonal Antibody at dilution of 1:25(?200)
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Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using XAB2 Polyclonal Antibody at dilution of 1:25(?200)

Documents

Further Information

Abbreviation:
XAB2
Background:
HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
100 kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human XAB2
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
0610041O14Rik;adapter protein ATH 55;Adapter protein ATH-55;Ath55;AV025587;Crn related protein kim1 ;crn-related protein kim1;DKFZp762C1015;HCNP;HCNP protein;HCRN;KIAA1177;NTC90;PP3898;Pre-mRNA-splicing factor SYF1;Protein HCNP;RNA splicing factor;SYF1;SYF1 homolog;SYF1 homolog; RNA splicing factor ;SYF1 pre mRNA splicing factor;SYF1;Xab2;XPA binding protein 2;XPA-binding protein 2
UNIProt ID:
Q9HCS7