PFKFB3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-53523-20uL | 20uL | £125.00 |
Quantity:
| E-AB-53523-60uL | 60uL | £172.00 |
Quantity:
| E-AB-53523-120uL | 120uL | £237.00 |
Quantity:
| E-AB-53523-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
PFKFB3
Background:
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
60 kDa
Concentration:
0.5 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human PFKFB3
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
Renal Carcinoma Antigen NY-REN-56;PFK/FBPase 3;IPFK2;PFK2
UNIProt ID:
Q16875