ATR Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-53308-20uL | 20uL | £125.00 |
Quantity:
| E-AB-53308-60uL | 60uL | £172.00 |
Quantity:
| E-AB-53308-120uL | 120uL | £237.00 |
Quantity:
| E-AB-53308-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
ATR
Background:
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:40-1:200, ELISA 1:5000-1:10000
Immunogen:
Synthetic peptide of human ATR
Purification method:
Antigen affinity purification
Target Synonym:
Ataxia telangiectasia and Rad3 related;Ataxia telangiectasia and Rad3-related protein;ATR;ATR;FCTCS;FRAP Related Protein 1;FRAP-related protein 1;FRP1;MEC1;MEC1 mitosis entry checkpoint 1 homolog;Protein kinase ATR;RAC3;Rad3 related protein;SCKL;SCKL1;Serine/threonine protein kinase ATR;Serine/threonine-protein kinase ATR
UNIProt ID:
Q13535