LFNG Polyclonal Antibody

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Elabscience
Product Code: E-AB-53116
Product Group: Primary Antibodies
Supplier: Elabscience
CodeSizePrice
E-AB-53116-20uL20uL£125.00
Quantity:
E-AB-53116-60uL60uL£172.00
Quantity:
E-AB-53116-120uL120uL£237.00
Quantity:
E-AB-53116-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Images

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Immunohistochemistry of paraffin-embedded Human tonsil tissue using LFNG Polyclonal Antibody at dilution of 1:60(?200)
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Immunohistochemistry of paraffin-embedded Human tonsil tissue using LFNG Polyclonal Antibody at dilution of 1:60(?200)

Documents

Further Information

Abbreviation:
LFNG
Background:
This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
42 kDa
Concentration:
1.08 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human LFNG
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
3-N-acetylglucosaminyltransferase lunatic fringe;Beta-1;Beta-13-N-acetylglucosaminyltransferase lunatic fringe;lfng;LFNG;O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;SCDO3
UNIProt ID:
Q8NES3