SRPK2 Polyclonal Antibody
Code | Size | Price |
---|
E-AB-53007-20uL | 20uL | £125.00 |
Quantity:
E-AB-53007-60uL | 60uL | £172.00 |
Quantity:
E-AB-53007-120uL | 120uL | £237.00 |
Quantity:
E-AB-53007-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Images
Further Information
Abbreviation:
SRPK2
Background:
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
0.96 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human SRPK2
Purification method:
Antigen affinity purification
Target Synonym:
Human serine kinase SRPK2 mRNA; complete cds;Serine kinase SRPK2;Serine/arginine rich protein specific kinase 2;Serine/arginine-rich protein-specific kinase 2;Serine/threonine protein kinase SRPK2 ;SFRS protein kinase 2;SFRSK2 ;SR protein specific kinase 2;SR-protein-specific kinase 2;SRPK2;SRPK2;SRSF protein kinase 2 C-terminal
UNIProt ID:
P78362