SETDB1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52933-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52933-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52933-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52933-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
SETDB1
Background:
SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.08 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human SETDB1
Purification method:
Antigen affinity purification
Target Synonym:
AU022152;EC 2.1.1.43;ERG-associated protein with SET domain;ESET;H3 K9 HMTase 4;H3-K9-HMTase 4;H3-K9-HMTase4;Histone H3 K9 methyltransferase 4;Histone H3-K9 methyltransferase 4;Histone-lysine N-methyltransferase SETDB1;KG1T;KIAA0067;KMT1E;Lysine N-methyltransferase 1E;MGC90670;mKIAA0067;SET domain bifurcated 1;Set domain protein;bifurcated;1;SETB1;Setdb1
UNIProt ID:
Q15047