EIF3C Polyclonal Antibody

EIF3C

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

0.6 mg/mL

Unconjugated

IHC 1:40-1:200, ELISA 1:5000-1:10000

Fusion protein of human EIF3C

Antigen affinity purification

Cell migration inducing protein 17;eIF 3c;eIF3 p110;eIF3-p110;eIF3c;EIF3C;EIF3CL;EIF3S8;EIF3S8 protein;Eukaryotic translation initiation factor 3 subunit 8 (110kD);Eukaryotic translation initiation factor 3 subunit 8 110kDa;Eukaryotic translation initiation factor 3 subunit 8;Eukaryotic translation initiation factor 3 subunit C

Q99613