NGEF Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52771-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52771-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52771-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52771-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
NGEF
Background:
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
82 kDa
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human NGEF
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
ARHGEF27;Eph receptor-interacting exchange protein;Eph-interacting exchange protein;EPHEXIN;Ephexin-1;Guanine nucleotide exchange factor; neuronal;Neuronal guanine nucleotide exchange factor;Ngef;NGEF
UNIProt ID:
Q8N5V2