POLH Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52741-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52741-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52741-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52741-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
POLH
Background:
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
78 kDa
Concentration:
0.78 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human POLH
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
DNA polymerase eta;FLJ16395;FLJ21978;Polh;POLH;polymerase DNA directed eta;RAD30;RAD30 homolog A;RAD30A;Xeroderma pigmentosum variant type protein;XP V;XPV
UNIProt ID:
Q9Y253