HLA-DRB4 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52725-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52725-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52725-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52725-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HLA-DRB4
Background:
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
30 kDa
Concentration:
0.84 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human HLA-DRB4
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
DR 4;DR beta 4 chain;DR4;DRB1 transplantation antigen ;DRB4;DRB4;HLA class II histocompatibility antigen;HLA class II histocompatibility antigen DR beta 4 chain ;HLA-DRB4;Human leucocyte antigen DRB4 ;Leukocyte antigen ;Major histocompatibility complex class II DR beta 4 ;MHC class II antigen DRB4;MHC class II antigen HLA DR beta ;MHC class2 antigen ;MHC HLA DR-beta chain
UNIProt ID:
P13762