HLA-DRB1 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52724-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52724-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52724-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52724-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HLA-DRB1
Background:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
30 kDa
Concentration:
1.14 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human HLA-DRB1
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
MHC Class II HLA-DR Beta 1 Chain;Human Leucocyte Antigen DRB1;MHC Class II Antigen DRB1*10;MHC Class II Antigen DRB1*11;MHC Class II Antigen DRB1*12;MHC Class II Antigen DRB1*13;MHC Class II Antigen DRB1*14;MHC Class II Antigen DRB1*15;MHC Class II Antigen DRB1*16;MHC Class II Antigen DRB1*1;MHC Class II Antigen DRB1*3;MHC Class II Antigen DRB1*4;MHC Class II Antigen DRB1*7;MHC Class II Antigen DRB1*8;MHC Class II Antigen DRB1*9;Lymphocyte Antigen DRB1c
UNIProt ID:
Q5Y7A7