TUBGCP4 Polyclonal Antibody

TUBGCP4

This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants.TUBGCP4 (Tubulin Gamma Complex Associated Protein 4) is a Protein Coding gene. Diseases associated with TUBGCP4 include Microcephaly And Chorioretinopathy, Autosomal Recessive, 3 and Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is TUBGCP6.

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

76 kDa

0.66 mg/mL

Unconjugated

WB 1:500-1:2000, ELISA 1:5000-1:10000

Fusion protein of human TUBGCP4

Refer to figures

Antigen affinity purification

76P;FLJ14797;Gamma tubulin complex component 4;Gamma tubulin ring complex protein (76p gene);Gamma tubulin ring complex protein;Gamma-ring complex protein 76 kDa;GCP 4;GCP4;Grip76;h76p;hGCP4;Hgrip76;TUBGCP 4;TUBGCP4;Tubulin gamma complex associated protein 4

Q9UGJ1