HLA-DMB Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52583-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52583-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52583-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52583-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
HLA-DMB
Background:
HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
29 kDa
Concentration:
1.38 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human HLA-DMB
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
class II antigen HLA-DM beta chain;class II histocompatibility antigen;Class II histocompatibility antigen M beta chain;D6S221E;DMB;HLA class II histocompatibility antigen DM beta chain;HLA-DM histocompatibility type;beta chain;M beta chain;Major histocompatibility complex class II DM beta;MHC class II antigen DMB;MHC class II antigen HLA DM beta chain;MHC class II HLA DMB;OTTHUMP00000029257;Really interesting new gene 7 protein;RING 7;RING7
UNIProt ID:
P28068