ALKBH8 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52350-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52350-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52350-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52350-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
ALKBH8
Background:
ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
75 kDa
Concentration:
0.6 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000
Immunogen:
Full length fusion protein
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
4930562C03Rik;8030431D03Rik;9430088N01Rik;ABH8;alkB alkylation repair homolog 8 (E. coli);alkB alkylation repair homolog 8;AlkB homologue 8;ALKB8;ALKBH8;Alkylated DNA repair protein alkB homolog 8;FLJ38204;MGC10235;OTTHUMP00000211286;OTTHUMP00000211287;Probable alpha-ketoglutarate-dependent dioxygenase ABH8;RGD1304687;S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8;tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
UNIProt ID:
Q96BT7