SPACA3 Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52300-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52300-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52300-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52300-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
SPACA3
Background:
SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.5 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:30-1:150, ELISA 1:5000-1:10000
Immunogen:
Full length fusion protein
Purification method:
Antigen affinity purification
Target Synonym:
1700025M08Rik;ALLP17;Cancer/testis antigen 54;CT54;LYC3;Lysozyme like sperm specific secretory protein ALLP17;Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17;Lysozyme-like protein 3;LYZL3;processed form;SACA3;SLLP1;SPACA3;Sperm acrosome associated 3;Sperm acrosome membrane-associated protein 3;Sperm lysozyme-like protein 1;Sperm protein reactive with antisperm antibodies;Sperm protein reactive with ASA
UNIProt ID:
Q8IXA5