PRKAR2A Polyclonal Antibody
| Code | Size | Price |
|---|
| E-AB-52196-20uL | 20uL | £125.00 |
Quantity:
| E-AB-52196-60uL | 60uL | £172.00 |
Quantity:
| E-AB-52196-120uL | 120uL | £237.00 |
Quantity:
| E-AB-52196-200uL | 200uL | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
Ice packs
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
Further Information
Abbreviation:
PRKAR2A
Background:
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Calculated MW:
46 kDa
Concentration:
0.8 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:35-1:200, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human PRKAR2A
ObservedMW:
Refer to figures
Purification method:
Antigen affinity purification
Target Synonym:
cAMP dependent protein kinase regulatory subunit alpha 2;cAMP dependent protein kinase regulatory subunit RII alpha;cAMP dependent protein kinase type II alpha regulatory chain;cAMP dependent protein kinase type II alpha regulatory subunit;cAMP-dependent protein kinase type II-alpha regulatory subunit;KAP2;KAP2;MGC3606;PKR 2;PKR2;PRKA R2;PRKAR 2;PRKAR2;PRKAR2A;Protein kinase A RII alpha subunit;Protein kinase cAMP dependent regulatory type II alpha
UNIProt ID:
P13861